An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2

Axon degeneration is a tightly regulated, self-destructive program that is a critical feature of many neurodegenerative diseases, but the molecular mechanisms regulating this program remain poorly understood.Here, we identify S-phase kinase-associated protein 1A (Skp1a), a core component of a Skp/Cullin/F-box (SCF)-type E3 activecare spitfire ubiqu

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Unmasking the Effects of Airbnb in Barcelona

The negative effects of tourism in mature destinations is a central debate in academia and everyday public life.The rise of tourism in the city of Barcelona was originally driven by the 1992 Olympic Games, which put it on the map of potential destinations of interest.Since then, the number of international visitors has increased year after year.Thi

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On-line anxiety level detection from biosignals: Machine learning based on a randomized controlled trial with spider-fearful individuals.

We present performance results concerning the validation for anxiety level detection based on trained mathematical models using supervised machine learning techniques.The model training is based on biosignals acquired in a randomized controlled trial.Wearable sensors were used to collect electrocardiogram, electrodermal activity, ackermans lace cur

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